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| Nardox - Sleep Aid Capsules |
Nardox helps in inducing natural sleep and restores mental peace. It reduces anxiety, restlessness and aggressiveness. And the best part is, it has no side effects, hangover or sedation. It is safe and non habit forming.
Following herbs are used in ful in inducing natural sleep:
Nardostachys jatamansi
Valeriana wallichii
Acorus calamus
Tinospora cordifolia
Nardostachys jatamansi
It is reported to have tranquilizing properties as per Ayurveda. It has been used alone or in the combination with TAGAR (Valerian wallchii) to relieve the anxiety symptoms. The infusion of root is administered in hysteria, palpitation of heart & other nervous diseases like convulsion & epilepsy.
Valeriana wallichii
Roots & rhizomes of Valeriana wallichii are used as sedatives & tranquilizer for the treatment of nervousness & hysteria. Valepotriate the active constituents possess definite sedative & tranquilizing activity in mice, cat & human. The root extract can be used as a day time sedative. A study conducted in 30 patients with anxiety disorder. Valeriana wallichii in combination with other was found to be useful in relieving anxiety symptoms.
Acorus calamus
Acorus calamus contains an essential oil having tranquilizing & sedative properties. In ayurveda it is used as anti- epileptic, psychoactive drug & has been reported to cure insanity & possess depressant action.
Tinospora cordifolia
Tinospora cordifolia is used as a general tonic & as a adaptogenic.The root possesses anti stress properties. When clinically evaluated for the anti stress & general health tonic properties, moderate degree of behavioral disorders, anxiety, restlessness & mental disorder were significantly improved by Tinospora cordifolia.
Indication & uses:
* Sleep disturbance, Insomnia
* Emotional stress, Irritability
* Anxiety, Tension
* Nervousness, Palpitation
* Natural sleep aid
Monograph:
Ever since the
philosopher Descartes has separated the transcendent mind from the mechanical
operations of the body, science has been even more concerned with accurately
resolving the body into its component parts. People have come to view all
illness as primarily a malfunction of the mechanical parts
(i. e. body) and
have lost sight of the importance of the psychological, social and
environmental influences on health & illness, and of the extraordinary
power of the mind to effect the body. Mood, attitude and belief can affect
virtually every chronic illness.
Apparently
disorders of (diseases affecting) mood, emotion and attitude i.e.
neuropsychological disorders has implication on the entire human system.
ANXIETY
Anxiety, characterized
by abnormal nervous tension and distortion of thinking, is not cardinal symptom
of many psychiatric disorders, but also an almost inevitable component of many
medical and surgical conditions. It is a universal human emotion, closely
allied with appropriate fear and often serving psychologically adaptive
purposes. An important clinical generalization is that anxiety is rather
infrequently a “disease” in itself, although in truth the anxiety associated
with many of the psycho-neurotic disorders, often seems to have an
incomprehensible life of its own. Thereby emphasizing the necessity for
anti-anxiety medications which can be frequently, appropriately and safely used
for treating primary and secondary anxiety.
CURRENT ANTIANXIETY THERAPY:
The primary
characteristics of anti-anxiety drugs in contrast to many other drugs that act
on central nervous system, is that they alter the mental state and behavior in
a predictable way.
While
pharmacotherapy with anti-anxiety drugs does not cure mental disorders in the
same sense that antibiotic cure infectious diseases, the available drugs do
control most symptomatic manifestations, behavioral deviance and facilitate the
patient’s tendency towards remission. Hence improves his/ her capacity for
social, occupational and familial adjustment.
Anti-anxiety
drugs, like other drugs used in psychiatry, can cause a wide range of adverse
effects. Many physiological systems may be affected, but central nervous system
(especially the higher cerebral functions) is particularly vulnerable. The most
common of all adverse effects is over sedation and hangover. This is a serious
problem while driving and while working in dangerous situations. Other major
side effects are impairment of intellectual functions, behavioral and performance
discrepancy, drowsiness and general apathy. Another major disadvantage of
currently prescribed anti-anxiety drugs is development of drug tolerance,
dependence and withdrawal symptoms like reflux anxiety, restlessness,
agitation, insomnia, delirium, convulsions and hypertension.
The aforementioned
disadvantages of currently prescribed anti- anxiety drugs necessitate the need
to develop new and safer anti-anxiety drugs. In compliance with the same quest,
Nirvana Wellness has formulated a
new herbal product, NARDOX, as an
effective Sleep-Aid.
NARDOX: AN IDEAL TRANQUILIZER.
NARDOX a herbal tranquilizer, is based on a balanced formula
derived from Medhya Rasayana drugs of ancient Indian form of medicine-
AYURVEDA. Each herb included herein has been reported to counteract the Anxiety
State by tranquilizing the patient. They also improve the memory span and
intelligence.
NARDOX, is an Herbal Sleep – Aid, has an edge over conventional antianxiety
drugs, because:
Being a herbal
preparation, it is safe and does not affect higher function.
It is devoid of
any side effect like over sedation, hangover etc.
It does not
produce drug tolerance, dependence and drug withdrawal symptoms.
Hence NARDOX can be very safely used to
reduce anxiety, tension, irritability, palpitation and also to improve memory,
thereby justifying the use of NARDOX
as a “nervine tonic”. The various medicinal herbs included in the formulation,
along with their common names are Nardostachys jatamansi (Jatamansi), Tinispora
cordifolia (Gudduchi), Valeriana wallichii (Tagar) and Acorus calamus (Vacha).
The subsequent
discussions provide a rationale for inclusion of each of the aforementioned
herbs in the currently introduced formulation: -
NARDOSTACHYS JATAMANSI:
N. jatamansi (Fam:
valerianacae), commonly known as Jatamansi. Charaka , Sushruta and Vagbhatta,
the three ancient manuscripts of Ayurveda, has recommended Jatamansi most
frequently in treatment of mental disorders as a sedative and tranquilizer. N.
jatamansi contains essential oil – Jatamansone, a ketonic sesquiterpene as its
major biologically active constituent. It also contains Jatamansic acid as one
of its constituents.
PHARMACOLOGY AND CLINICAL TRIALS :
N. jatamansi has been universally known for its tranquilizing
properties in the Indian system of medicine – Ayurveda. It has been used in
Ayurveda, either alone or in combination with Valeriana jatamansi for treating
various anxiety disorders. The infusion of roots is administered in hysteria,
palpitation of heart and in various other nervous diseases like epilepsy and
convulsions (Arora, 1965).
Jatamansone also
exerted tranquilizing action in mice and monkey (Arora et al., 1962). The oil ,
also potentiated phenobarbital –induced narcosis in rats, reduced the
conditional avoidance response in cats and reduced the rat brain serotonin
content (Hamied et al ., 1962). The mode of action of Jatamansone is to reduce
the brain levels of 5 hydroxytryptamine by impairing the biosynthesis of
serotonin in the brain tissue (Arora et al .,1962).
In an open trial
of 4 weeks in 25 patients with anxiety disorders, N. Jatamansi in combination
with other herbal drugs was found to be useful in relieving the anxiety
symptoms, wherein the onset of action was observed by the end of 2nd
week and the maximum response by the end of the 4th week (Shah, et
al., 1994). A double blind clinical trial conducted in 28 hyperkinetic children
below 14 years of age for 11 months showed that jatamansone improved the
behaviour significantly (Gupta et al., 1968). Jatamansone was also found to
reduce the mental symptoms in the schizophrenic patients (Mahal et al., 1976).
In Ayurveda, Jatamansi has been
reported to improve intellect and memory. The root infusion can be used in
treatment of menopausal symptoms and indigestion (Thakur et al ., 1989).
Jatamansone also exhibited anti- emetic properties in dogs and reduced
aggressiveness in monkeys (Rastogi et al., 1990).
TINOSPORA CORDIFOLIA:
T. cordifolia (Fam
: Menispermaceae) commonly known as Guduchi. It has been reported to possess a
wide range of therapeutic activity. It has been used in the traditional system
of medicine as an Indian bitter. In Ayurveda, the drug is administered along
with piper longum root , to prevent gastric degradation of food materials and
to improve the digestion. It contains Tinosporin, Tinosporon, Cordifolide,
Tinosporon and Tinosporine as its major biologically active
constituents. The
leaves also contain octasanol and beta – sitosterol (Dixit et al., 1971; Kudrat
– I –Khuda, 1964).
PHARMOCOLOGY
AND CLINICAL TRIALS:
In Ayurveda, T.
cordifolia categorised as “Rasayana” is used as a general tonic and as an
adaptogenic. The root possesses anti stress properties (WOI, 1976; Thatte and
Dahanukar, 1989). Mortality rate in E. coli induced peritonitis was
significantly reduced with T. cordifolia treatment (Dahanukar et al., 1988 ;
Rage et al., 1989).
Sheth et al.,
(1991) and Sharan et al., (1991) have clinically evaluated the antistress and
general health tonic properties of T. cordifolia wherein moderate degree of
behavioral disorders and mental disorders were significantly improved. Increase
in IQ levels was also significant. T. cordifolia also protected cholestatic
patients against E. coli infection (Thatte et al., 1989).
The root possess
antileprotic and anti- malarial activity (WOI,1976). The extracts of T.
cordifolia showed hepatoprotective effect against carbon tetrachloride induced
hepatotoxicity (peer et al., 1989).
3). VALERIANA WALLICHII:
V. wallichii (Fam: Valerianaceae) commonly known as
Tagar. In Ayurveda, the extracts of V. wallichii have been cited for its
neuroleptic and sedative properties. V. wallichii contains valepotriates
(triesters of polyhydroxy alcohol with valeric, isovaleric and isocaproic acid)
as its active constituents. The other constituents identified are archidic
acid, haspertonic acid and caproic acid.
PHARMACOLOGY
AND CLINICAL TRIALS:
Roots and rhizomes of V. wallichii are used as
sedative and tranquilizer for the treatment of hysteria, nervous unrest, hypochondriasis
and similar emotional states. Valepotriates were found to possess definite
sedative and tranquilizing activity in mice, cats and humans. Valepotriates has
also been reported to improve coordination and diminish restlessness, anxiety
and aggressiveness in animals without adverse effect on reactivity (Klaus et
al., 1969). The hypnotic effect in mice was antagonized by a mixture of
Valepotriates (100 mg/ kg orally) (Klaus et al., 1969). It also exerted
sedative, spasmolytic, CNS depressant and antitumour effect (Sharma et al.,
1989). The root extract can be used as day- time sedative since it does not
have synergy with alcohol and doesn’t slow down the reflexive response (Hobbs,
1990; Monograph, German Min. Health, 1989).
Twenty epileptic
patients were tested for cognitive functions following sodium valproiate
monotherapy. Progressive improvement in attention, intelligence, immediate
recall and visuospatial functions, with no charge in orientation and recent and
remote memory was observed (Jha et al., 1992). In another open trial of 4 weeks
conducted in 30 patients with anxiety disorders, V. wallichii in combination
with other herbal drugs was found to be useful in relieving anxiety symptoms ,
wherein onset of effect and maximal effect was observed by the end of 2nd and 4th week respectively. Long
term treatment upto 12 weeks improved the efficacy of the drug quantitatively,
but was found to be devoid of any side effects (Shah et al ., 1994).
4). ACORUS CALAMUS:
A.calamus (Fam:
Araceae) commonly known as Vacha. The plant extracts have been extensively used
in the traditional Indian system of medicine as a sedative, in the treatment of
epilepsy, insanity, and as a tranquilizer. It contain the two isomeric
substances, Asarone and B- Asarone as its major, biologically active chemical
constituent.
PHARMACOLOGY
AND CLINICAL TRIALS:
A.calamus essential oil was found to possess
tranquilizing and sedative properties comparable to that of chlorpromazine and
reserpine (Handa, 1994). In Ayurveda, A. ocalamus is used as antiepileptic ,
psychoactive drug and has been reported to cure insanity, promote intellect and
intelligence. The aqueous and alcoholic root extracts exhibits depressant
action (Bose et al., 1960). The extracts are also used in treatment of petitmal
epilepsy (Martis et al., 1991). Essential oils of A. calamus also showed
sedative and tranquilizing action in rats, cats and dogs (Rastogi et al., 1965;
Sharma et al., 1961).
Asarone and B-
Asarone has been reported to potentiate the hypnotic activity of anaesthetic
agents, produce significant reduction in rectal temperatures in mice and shows
anti- cholinergic action in mice (Sharma et al., 1961; Rastogi et al., 1962).
In an open trial
of 4 weeks A. calamus in a composite formulation was reported to be useful in
relieving anxiety symptoms in 30 patients with anxiety disorders. In long term
A. calamus (for 12 weeks) showed quantitative improvement in alleviating
anxiety disorders without producing any side effects (Shah et al., 1994).
The essential oils
also showed smooth muscle relaxant properties as well as antispasmodic action
against various spasmogens (Dhalla et al., 1962). It is also useful in
preventing electrically induced convulsions in hind limbs of the rats (Madan et
al., 1960). It blocks the neuromuscular junctions, both pre and post
synoptically by interfering with the calcium and magnesium ion effects
respectively (Panchal et al., 1989). Both asarone and B- asarone showed cardiac
depressant activity, along with stoppage of frog heart in diastole and moderate
hypotensive action in anaesthesised dogs. (Rastogi et al., 1990).
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