Arthroton is a powerful Anti- Inflammatory and Anti- Arthritic formulation.
• Ensures speedy relief from Inflammatory, pain & stiffness smooth,
• Pain free joint movements
• Supports power of digestion
• Eliminates metabolic toxic by products
• Controls the root cause of Rheumatic disorders
Composition: It contains following standardized extracts:
Commiphora mukul
Ricinus communis
Boerhavia difffusa
Turmeric (Cucuma longa)
Zingiber officinalis
Withania ashwagandha
Commiphora mukul
Commiphora Mukul is comparable to hydrocortisone. A gum exudates of Guggul is now well documented & proven for it’s anti inflammatory & anti arthritic activity.
Ricinus communis
Ricinus Communis has been used for it’s anti inflammatory, analgesic & anti rheumatic properties. It also provides lubrication to the joints & facilitates their movements.
Boerhavia difffusa
Boerhavia Difffusa has been reported to have a significant anti inflammatory property. It is found to exhibit diuretic activity which helps to eliminate toxic elements from the body.
Turmeric (Cucuma longa)
Cucuma Longa has exhibited anti inflammatory & analgesic properties in various pharmacological studies. It also enhances the function of digestive system.
Zingiber officinalis
Zingiber Officinalis possesses analgesic & anti rheumatic properties. It has been used as a drug of choice in rheumatic conditions. According to Ayurveda it acts as a carminative & digestive, restoring metabolic activities in a normal mode which are disturbed due to improper digestion.
Withania ashwagandha
Withania Ashwagandha also known as Indian Ginseng, has been known to help reduce the discomfort associated with arthritis. Ashwagandha has been shown to be effective in reducing the pain of arthritis.
Indications:
* Osteo- arthritis
* Rheumatoid arthritis
* Degenerative joint disease
• Ensures speedy relief from Inflammatory, pain & stiffness smooth,
• Pain free joint movements
• Supports power of digestion
• Eliminates metabolic toxic by products
• Controls the root cause of Rheumatic disorders
Composition: It contains following standardized extracts:
Commiphora mukul
Ricinus communis
Boerhavia difffusa
Turmeric (Cucuma longa)
Zingiber officinalis
Withania ashwagandha
Commiphora mukul
Commiphora Mukul is comparable to hydrocortisone. A gum exudates of Guggul is now well documented & proven for it’s anti inflammatory & anti arthritic activity.
Ricinus communis
Ricinus Communis has been used for it’s anti inflammatory, analgesic & anti rheumatic properties. It also provides lubrication to the joints & facilitates their movements.
Boerhavia difffusa
Boerhavia Difffusa has been reported to have a significant anti inflammatory property. It is found to exhibit diuretic activity which helps to eliminate toxic elements from the body.
Turmeric (Cucuma longa)
Cucuma Longa has exhibited anti inflammatory & analgesic properties in various pharmacological studies. It also enhances the function of digestive system.
Zingiber officinalis
Zingiber Officinalis possesses analgesic & anti rheumatic properties. It has been used as a drug of choice in rheumatic conditions. According to Ayurveda it acts as a carminative & digestive, restoring metabolic activities in a normal mode which are disturbed due to improper digestion.
Withania ashwagandha
Withania Ashwagandha also known as Indian Ginseng, has been known to help reduce the discomfort associated with arthritis. Ashwagandha has been shown to be effective in reducing the pain of arthritis.
Indications:
* Osteo- arthritis
* Rheumatoid arthritis
* Degenerative joint disease
Monograph:
ARTHROTON: Joint Pain Reliever
Today about 15%
of the population is afflicted with arthritis or related disorder, and
percentage is growing because the standard medical treatment offers only
symptomatic relief.
Arthritis is an
inflammation of the joints, surrounding tendons, ligaments and cartilage. It
can affect almost every joint of the body: from feet to knees, shoulders, back,
wrists and even the fingers. There is variety of arthritic conditions but most
commonly found are Osteoarthritis, Gout and Rheumatoid arthritis.
OSTEO-ARTHRITIS
This condition is closely related with
process of ageing. It tends to affect the larger weight bearing joints of the
spine, hip and knees. In the beginning, the joint cartilage starts
deteriorating and finally restricts the movements. The symptoms include: mid
early morning stiffness, restricted and painful movements of the joints, soft
tissue and bony swellings, etc. The characteristic feature of osteo-arthritis
is creaking and cracking of joints on movement.
RHEUMATOID
ARTHRITIS
It is a serious
and extremely painful joint disorder, often resulting in crippling impairment
for young and old alike. Synovial membrane is normally well-lubricated
membrane, which lines the joint cavity in order to ease the joint movement. In this
condition, this membrane is disabled causing distortion of the joints. This
distortion is prominent in the smaller joints.
The symptoms
include inflammation, stiffness, tenderness and painful movements of the
smaller joints and even deformity. Fatigue, low-grade fever and depression are
other symptoms. The severity of the disease varies from time to time and
becomes better or worse in unexplainable manner. It is classified as an Auto-immune
disease in which the body attacks it own tissues.
GOUT
This disease
develops due to improper elimination or excessive production of uric acid. When
the level of uric acid in the body exceeds normal level, it crystallizes in the
joint cartilage, synovial membrane and fluid. This deposition leads to sharp,
needle like pain in the joints, loss of mobility as well as fever and
depression. These patients are at higher risk of heart and kidney problems.
TREATMENT
Currently
prescribed therapeutic interventions are intended only to relieve the signs and
symptoms of the disease. None of this drug is able to modify the course of the
disease. These drugs include Aspirin, NSAIDs ie.non-steroidal anti-
inflammatory drugs (Ibuprofen, Piroxicam, Naproxen etc.), Glucocorticoids and a
group of disease modifying drugs (Gold compounds, Antimalarials and
D-penicillamine). All of these drugs are known to exert anti-inflammatory and
analgesic effect and slow down the progress of the disease upto some extent.
The
disadvantage of these is, they are associated with a wide spectrum of undesirable
side effects like: gastrointestinal intolerance, liver function abnormalities
rash and aggravation of asthma or allergic rhinitis. Gluco- corticoids may
develop Osteoporosis even at a low dose therapy. The patients treated with the
group of disease modifying agents need careful observation, as they are likely
to develop systemic toxicity. Furthermore, elderly patients on diuretics are at
higher risk for certain side effects.
Thus there is
no consistent advantage of these drugs with respect to the incidence or
severity of toxic manifestations.
The plants used
in formulation of ARTHROTON
are well known for their highly potent anti-arthritic and anti-rheumatic
properties. Ayurvedic practitioners prove their efficacy over the centuries.
ARTHROTON gives best results as an anti-inflammatory and
analgesic agent and is devoid of the side effects of the steroidal or non-
steroidal anti- inflammatory drugs.
ARTHROTON deals with the root cause of rheumatic disease to
eliminate them. Ayurveda asserts that rheumatic disorders are the result of the
metabolic disturbances due to improper digestion.
ARTHROTON helps to modulate the metabolic activities and
contributes to functional improvement.
ARTHROTON eliminates the toxic metabolites from the body with
the help of diuretic agents.Thus accelerating recovery from joint pain.
ARTHROTON effectively reduces the pain, inflammation and
stiffness of the joints and improves their movements. It acts as a muscle
relaxant and facilitates the ability to grip.
ARTHROTON endows joint lubrication and prevents
further distortion of the joints. It aids regenerative processes and helps to
alter the course of the disease.
ARTHROTON motivates regression of rheumatic and arthritic
conditions and provides a lasting relief from joint pain.
ARTHROTON is a comprehensive therapy for musculoskeletal
disorders, having combination of following herbs:
Commiphora
mukul (Guggul)
Ricinus
communis (Erand)
Curcuma longa (Haridra)
Boerhaavia
diffusa (punarnava)
Zingiber
officinale (Shunthi)
Withania somnifera
(Ashwagandha)
Subsequent
reports of various trials specify the motive of inclusion of these components
in ARTHROTON:
1) COMMIPHORA MUKUL (GUGGUL)
C.mukul is a time tested anti-inflammatory,
analgesic and anti-rheumatic agent. It has been used to relieve arthritic and
rheumatic conditions. The guggul preparations like Mahayogaraj guggul, Yogaraj
guggul, Simhananda guggul, etc. are well known for better and faster results
and hence are very popular amongst Ayurvedic practitioners.
PHARMACOLOGICAL
AND CLINICAL TRIALS
The action C.mukul
against Brownlee’s formaldehyde-induced arthritis in albino rats has been
reported. The oleoresin of guggul and its fractions were screened against
Browenlee’s arthritis model and granuloma pouch and cotten pellet tests in
normal and belaterally adrenalectamized albino rats. The oleoresin showed
significant anti-inflammatory and anti-arthritic effect in all models at a dose
12.5 mg /100g body wt. and above. The acid fraction of guggul showed this
effect even in the adrenalectamized rats (Quoted by Satyavati, 1991).
Significant
anti-inflammatory and anti-arthritic effects of C.mukul was reported against
carrageenin -induced rat paw edema granuloma pouch as well as adjuvant
arthritis (Quoted by Satyavati, 1991).
Significant
anti-inflammatory and anti-arthritic effects of a steroid fraction of C.mukul
against carrageenin edema in rat paw and secondary inflammation caused by
Freund’s adjuvant arthritis has been reported (Dhanukar et al., 1983).
The 250 mg /kg
and 500 mg/ kg doses of C.mukul
when administered twice at 18 and 1 hourprior to the injection of carrageenin,
produced dose dependant inhibition of rat paw edema. It produced peak
anti-inflammatory effect with 18 hours pre-treatment Schedule when concentrated
extract of the same was administered as a single dose of 500 mg/kg. This
confirms that C.mukul possesses anti-inflammatory activity of prolonged
duration (Sharma et.al.1987).
The anti- inflammatory activity of the
aqueous extract of C.Mukul has been reported. It significantly inhibited
both the maximal edema response and the total edema response during 6th hour of
carrageenin -induced rat paw edema
(Duwiejua et al.1993).
Clinical trial
with purified C.mukul has been carried out in 35 patients of rheumatoid
arthritis in order to assess its antirheumatic activity, dose requirement
resistance, development and side effects on hematology. From the results
obtained it has been indicated that Guggul acts as an analgesic agent without
any toxic or side effect (Vyas et al., 1987).
Three compound
Ayurvedic preparations (with C.mukul gum as a main ingredient) were
tested for anti - inflammatory activity in rats using the formaline -induced
arthritis and the granuloma pouch method. All the three preparations showed a
significant anti-inflammatory effect (Quoted by satyavati, 1991).
A Clinical
trial was conducted to evaluate the efficacy of an Ayurvedic drug , having C.mukul
as a chief component ,in osteo-arthritis .After 2 months of the treatment, 10%
of the cases were cured, 13% got marked relief,50% showed moderate relief , 20%
got mild relief and 7% remained unchanged.Whereas total 70 % of cases of
control group remained unchanged. The severity of the disease increased in 30%
( Sannd et, 1994 ).
Oral
administration of Vatahari Guggul, a composite drug having C.mukul as a
major ingredient.was found to be useful in the treatment of Rheumatic diseases
(Pandey et., 198 1986)
2) RICINUS COMMUNIS (ERAND)
R.communis has
been used for its anti -inflammatory, analgesic properties. It also acts as a
demulcent providing lubrication to the joints and facilitating their movements.
PHARMACOLOGICAL
AND CLINICAL TRIALS
Fraction II of
the crude alcohol extract of R. Communis was found to have a potent anti
-inflammatory activity. It was found to be effective in granuloma pouch method
in the dose of 150 mg/kg. There was a considerable decrease in the volume of
exudate formed, weight of the pouch and average W.B.C. count per cu. mm as compared to that of controls.
Furthermore its 10mg per 100 gm dose was found to be more potent than acetyl
salicylic acid given in the dose 30 mg/100 gm (Sharma et al., 1969).
3) CURCUMA LONGA (HARIDRA)
It possesses
anti-inflammatory and analgesic properties. It also enhances the function of
digestive system.Thus consummating the requirements of an antirheumatic drug
according to Ayurveda.
PHARMACOLOGICAL
AND CLINICAL TRIALS
The data
reviewed indicate that extracts of C.longa exhibit anti-inflammatory
activity. The curcumin and the volatile oil are responsible for this action. In
vitro curcumin exhibited antispasmodic activity (Ammon et al., 1991).
Employing the
main constituents of C.longa, curcumin, its effect on the pathway of
arachidonic acid cascade in stimulated polymorphnuclear neutrophils and
platelets have been studied. It exhibited an anti-oxidative effect in Fe/
ascorbate -induced peroxidation of arachiodonic acid. Further, it inhibited the
formation of cyclo-oxygenase and 5- lipoxygenase as
well as 12- lipoxygenase products (Ammon et al., 1992).
Curcumin from C.longa,
which was demonstrated to act as anti-inflammatory in vivo animals models, was
studied in a set of vitro experiments in order to elucidate the mechanism of
its beneficial effects. It inhibited the 5- lipoxygenase activity in rat
peritoneal neutrophils as well as the cyclo oxygenase and the 12-lipoxygenase
activities in human platelets.In cell free peroxydation system curcumin
excerted strong anti-oxydative activity. Thus its effects on the dioxygenases
are probably due to its reducing capacity (Ammon et al., 1993).
An indigenous
preparation, having C.longa as one of the major ingredients, was tested
in 42 patients of Osteo-arthritis. It produced a significant drop of pain and
disability score (Kulkarni et al., 1991).
The clinical
efficacy of an Ayurvedic drug having C.longa as a major component was
evaluated in placebo control and 20 patients Rheumatoid arthritis. Treatment
with drugs for 3 months produced significantly greater relief of pain,
decreased morning stiffness, decrease in Ritche Articular index and joint score.
A significant drop in E.S.R was observed in the drug treated patients (Kulkarni
et al.,
1992)
4) BOERHAAVIA DIFFUSA (PUNARNAVA)
It acts as an
anti-inflammatory agent. It also helps to eliminate toxic elements from the
body through urine, as it possesses diuretic activity.
PHARMACOLOGICAL
AND CLINICAL TRIALS
The aqueous and acetone extracts of the root
of diffusa in a dose of 4 mg/100 gm of body wt. each showed significant
anti-inflammatory activity in carrageenin-induced edema and formaldehyde-induced arthritis in
albino rats. The nitrogen-containing base inhibited the increased serum amino
transferase activity in arthritic animals similar to that of hydrocortisone
(Ball et al., 1968).
A comparative
study, for the assessment of anti inflammatory activity of the different parts
of B.diffusa in carrageenin -induced hind paw oedema was carried out by
Mudgal, 1975. Intraperitonial doses of the test extracts of B .diffusa have
shown analgesic property in male albino rats. The anti-inflammatory activity of
alcoholic extract of roots and leaves was more significant as compared to that
of whole plant.
Anti-inflammatory
effect of various extracts of root of B.diffusa was examined in
carrageenin-induced oedema and formaldehyde-induced arthritis in albino rats.
Acetone extract of B.diffusa was found to possess most potent
anti-inflammatory activity. Aqueous extract and alkaloid fractions
significantly inhibited the increased serum aminotransferase activity in
arthritic animals similar to that of hydrocortisone. Liver ATP (adenosine
triphosphate phosphohydrolase) activity in arthritic animals was also increased
by these fractions and aqueous extract (Bhalla et al., 1971).
Singh et al.,
(1972) have studied the diuretic activity of B.diffusa. The alcoholic
extract of roots was found to be more effective than the whole plant and stems.
5) ZINGIBER OFFICINALE (SHUNTHI)
Shunthi
possesses analgesic and antirheumatic properties. It has been used as a drug of
choice in rheumatic conditions. According to Ayurvedic concepts, it acts as a
carminative and digestive, restoring metabolic activities in a normal mode,
which are disturbed due to improper digestion.
PHARMACOLOGICAL
AND CLINICAL TRIALS
(6) - Gingerol
and (6) - shogaol, active constituents of Z.officinale, were found to
produce an inhibition of spontaneous motor activity and have antipyretic and
analgesic effects ( Suekawa et al., 1984).
WITHANIA ASHWAGANDHA (ASHWAGANDHA)
W. Ashwangandha
(Fam: Solanaceae) commonly known as Ashwagandha is the cultivated variety of W.
somnifera. The chemical constituents of We.ashwagandha
consists of steroidal lactone withafterin-A, withanolides, Flavonoids and
several alkaloids as its active constituents. W. ashwagandha, apart from other
morphological difference, also contains starch in significant proportion,
instead, as found in W.somnifera.
PHARMACOLOGY AND CLINICAL TRIALS
W. ashwagnadha
has been reported to possess growth promoting properties in weanling rats and
in their progeny. It also reduces the adernal activity and plasma content of
corticoids (Sharma et al., 1985). Withafterin- A. active constituents of W.
ashwagandha exhibited significant anti-stress activity in widely different
stress situation like, Pentelene tetrazole induced defeacation and urination,
forced swimming test in mice and Restraint stress induced gastric ulceration in
mice (Battacharya et. Al. 1987), Sitoindosides IX and X of W. ashwangandha also
exhibited adaptogenic and immunostimulatory activities (Ghosal et al.1988).
sharma et al.,(1991) have showed that W. ashwagandha reduces concentration of
monoamines in the brain during stress (Bhattacharya et al., 1989). These
immuno-modulating and adaptogenic properties are attributed to its active
constituent Withafterin – A (Bhar e al., 1982).
Jayaram et al.,
(1993) have reported that W. ashwagandha exhibits immunomodulatory,
cytoprotective, growth promoting and adaptogenic properties, when administered
to patients complaining of fatigue and lethargy, without any diagnosed disease.
Seshadri et. Al..(1983) have reported that in a double blind trial, Ashwagandha
significantly increased the body weight, total protein content and haemoglobin
content. Kulkarni et al., (1983), have reported that methanolic extract of W.
ashwagandha acts via barbiturate modulatory centre of GABA receptors.
Khandeparkar et al., (1981) have concluded that W. ashwagandha possess
significant anti – fatigue property.
Kulkarni et
al.,(1993) have reported that methanolic extract of W ashwagandha prevented
Pentelene tetrazole induced convulsions in a dose dependent manner (complete
protection at 200 mg/kg dose). W. ashwagandha has also been found to possess
antibiotic and antibiotic and antibacterial activity (WOI. 1976). Sethi (1970);
Singh et al.,(1978); Hazeena et al., (1988) have mentioned that W. ashwagandha
exhibits anti-inflammatory and antiarthritic activity in chronic animal models.
Increase in RBC count, WBC count and mitotic index following treatment with
alcoholic extract of W. ashwgandha roots. Antitumour activity of W. ashwagandha
has been observed by Verma, (1982) and Shohat et al.,(1970).
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